Visual atrophy rating scales and amyloid PET status in an Alzheimer's disease clinical cohort.

ABSTRACT:

Objectives

Visual rating scales (VRS) are the quantification method closest to the approach used in routine clinical practice to assess brain atrophy. Previous studies have suggested that the medial temporal atrophy (MTA) rating scale is a reliable diagnostic marker for AD, equivalent to volumetric quantification, while others propose a higher diagnostic utility for the Posterior Atrophy (PA) scale in early-onset AD.

Methods

Here, we reviewed 14 studies that assessed the diagnostic accuracy of PA and MTA, we explored the issue of cut-off heterogeneity, and assessed 9 rating scales in a group of patients with biomarker-confirmed diagnosis. A neuroradiologist blinded to all clinical information rated the MR images of 39 amyloid-positive and 38 amyloid-negative patients using 9

SUBMITTER: Loreto F 

PROVIDER: S-EPMC10109315 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature