Sex and estrous cycle affect experience-dependent plasticity in mouse primary visual cortex.

ABSTRACT: Sex hormones can affect cellular physiology and modulate synaptic plasticity, but it is not always clear whether or how sex-dependent differences identified in vitro express themselves as functional dimorphisms in the brain. Historically, most experimental neuroscience has been conducted using only male animals and the literature is largely mute about whether including female mice in will introduce variability due to inherent sex differences or endogenous estrous cycles. Though this is beginning to change following an NIH directive that sex should be included as a factor in vertebrate research, the lack of information raises practical issues around how to design experimental controls and apply existing knowledge to more heterogeneous populations. Various lines of research suggest that visu

SUBMITTER: Schecter RW 

PROVIDER: S-EPMC10109517 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature