A Pragmatic Framework for the Application of New Approach Methodologies in One Health Toxicological Risk Assessment.

ABSTRACT: Globally, industries and regulatory authorities are faced with an urgent need to assess the potential adverse effects of chemicals more efficiently by embracing new approach methodologies (NAMs). NAMs include cell and tissue methods (in vitro), structure-based/toxicokinetic models (in silico), methods that assess toxicant interactions with biological macromolecules (in chemico), and alternative models. Increasing knowledge on chemical toxicokinetics (what the body does with chemicals) and toxicodynamics (what the chemicals do with the body) obtained from in silico and in vitro systems continues to provide opportunities for modernizing chemical risk assessments. However, directly leveraging in vitro and in silico data for derivation of human health-based reference values has not received re

SUBMITTER: Magurany KA 

PROVIDER: S-EPMC10109535 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature