Sustained upregulation of widespread hippocampal-neocortical coupling following memory encoding.

ABSTRACT: Systems consolidation of new experiences into lasting episodic memories involves hippocampal-neocortical interactions. Evidence of this process is already observed during early post-encoding rest periods, both as increased hippocampal coupling with task-relevant perceptual regions and reactivation of stimulus-specific patterns following intensive encoding tasks. We investigate the spatial and temporal characteristics of these hippocampally anchored post-encoding neocortical modulations. Eighty-nine adults participated in an experiment consisting of interleaved memory task- and resting-state periods. We observed increased post-encoding functional connectivity between hippocampus and individually localized neocortical regions responsive to stimuli encountered during memory encoding. Post-enc

SUBMITTER: Folvik L 

PROVIDER: S-EPMC10110434 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature