Genetic and environmental factors influencing neonatal resting-state functional connectivity.

ABSTRACT: Functional magnetic resonance imaging has been used to identify complex brain networks by examining the correlation of blood-oxygen-level-dependent signals between brain regions during the resting state. Many of the brain networks identified in adults are detectable at birth, but genetic and environmental influences governing connectivity within and between these networks in early infancy have yet to be explored. We investigated genetic influences on neonatal resting-state connectivity phenotypes by generating intraclass correlations and performing mixed effects modeling to estimate narrow-sense heritability on measures of within network and between-network connectivity in a large cohort of neonate twins. We also used backwards elimination regression and mixed linear modeling to identify s

SUBMITTER: Blanchett R 

PROVIDER: S-EPMC10110449 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature