Age-related reorganization of functional network architecture in semantic cognition.

ABSTRACT: Cognitive aging is associated with widespread neural reorganization processes in the human brain. However, the behavioral impact of such reorganization is not well understood. The current neuroimaging study investigated age differences in the functional network architecture during semantic word retrieval in young and older adults. Combining task-based functional connectivity, graph theory and cognitive measures of fluid and crystallized intelligence, our findings show age-accompanied large-scale network reorganization even when older adults have intact word retrieval abilities. In particular, functional networks of older adults were characterized by reduced decoupling between systems, reduced segregation and efficiency, and a larger number of hub regions relative to young adults. Exploring

SUBMITTER: Martin S 

PROVIDER: S-EPMC10110455 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature