Dysfunction of circulating CD3⁺CD56⁺ NKT-like cells in type 2 diabetes mellitus.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is associated with increased incidence and mortality of many cancers and infectious diseases. CD3⁺CD56⁺ NKT-like cells play pivotal roles in tumor surveillance and infection control. However, little is known about potential alterations in circulating NKT-like cells in T2DM patients. In this study, we found that the frequency and absolute counts of circulating NKT-like cells were significantly lower in patients with T2DM compared to healthy volunteers. Moreover, in T2DM patients, NKT-like cells were impaired in their production of IFN-γ and TNF-α as well as degranulation capacity. The expression of activating receptor NKG2D was markedly decreased on NKT-like cells in T2DM patients, while the expression of inhibitory receptors Tim-3 and L

SUBMITTER: Tang L 

PROVIDER: S-EPMC10110473 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature