Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice.

ABSTRACT: Despite extensive research on astrocytic Ca²⁺ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell recordings, we show two distinct astrocytic Ca²⁺ signals in the murine barrel cortex: a small, long-lasting Ca²⁺ increase during sleep and a large, widespread but short-lasting Ca²⁺ spike when aroused. The large Ca²⁺ wave in aroused mice was inositol trisphosphate (IP3)-dependent, evoked by the locus coeruleus-norepinephrine system, and enhanced sensory input, contributing to reliable sensory transmission. However, the small Ca²⁺ transient was IP3-independent and contributed to decreased ext

SUBMITTER: Wang F 

PROVIDER: S-EPMC10110578 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature