Developmental changes in electrophysiological properties of auditory cortical neurons in the Cntnap2 knockout rat.

ABSTRACT: Disruptions in the CNTNAP2 gene are known to cause language impairments and symptoms associated with autism spectrum disorder (ASD). Importantly, knocking out this gene in rodents results in ASD-like symptoms that include auditory processing deficits. This study used in vitro patch-clamp electrophysiology to examine developmental alterations in auditory cortex pyramidal neurons of Cntnap2^-/- rats, hypothesizing that CNTNAP2 is essential for maintaining intrinsic neuronal properties and synaptic wiring in the developing auditory cortex. Whole cell patch-clamp recordings were conducted in wildtype and Cntnap2^-/- littermates at three postnatal age ranges (P8-12, P18-21, and P70-90). Consistent changes

SUBMITTER: Mann RS 

PROVIDER: S-EPMC10110732 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature