SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches.

ABSTRACT:

Background

Metastasis is the major cause of high recurrence and mortality of hepatocellular carcinoma (HCC). Unfortunately, there are few reports on effective biomarkers of HCC metastasis. Previous studies have reported that SAA1 may be a predictor and prognostic biomarker for multiple malignant tumors. However, the role of SAA1 in HCC has not yet been investigated.

Methods

We applied RNA sequencing and proteomics analysis to investigate the expression landscape of HCC cell lines and patient serum, respectively. SAA1 is a common key gene and listed as a candidate biomarker of HCC metastasis. It was validated in two cell lines, 107 participants serum, and 63 matched HCC and adjacent non-tumorous liver tissues. Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx), and

SUBMITTER: Li G 

PROVIDER: S-EPMC10110885 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature