MiRNA deregulation and relationship with metabolic parameters after Mediterranean dietary intervention in BRCA-mutated women.

ABSTRACT:

Background

Breast cancer onset is determined by a genetics-environment interaction. BRCA1/2 gene alterations are often genetically shared in familial context, but also food intake and hormonal assessment seem to influence the lifetime risk of developing this neoplasia. We previously showed the relationship between a six-months Mediterranean dietary intervention and insulin, glucose and estradiol levels in BRCA1/2 carrier subjects. The aim of the present study was to evidence the eventual influence of this dietary intervention on the relationship between circulating miRNA expression and metabolic parameters in presence of BRCA1/2 loss of function variants.

Methods

Plasma samples of BRCA-women have been collected at the baseline and at the end of the dietary intervention. More

SUBMITTER: De Summa S 

PROVIDER: S-EPMC10110888 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature