Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients.

ABSTRACT:

Importance

Thyroid storm is the most severe form of thyrotoxicosis, with high mortality, and is treated with propylthiouracil and methimazole. Some guidelines recommend propylthiouracil over methimazole, although the difference in outcomes associated with each treatment is unclear.

Objective

To compare outcomes associated with use of propylthiouracil vs methimazole for the treatment of thyroid storm.

Design, setting, and participants

This comparative effectiveness study comprised a large, multicenter, US-based cohort from the Premier Healthcare Database between January 1, 2016, and December 31, 2020. It included 1383 adult patients admitted to intensive or intermediate care units with a diagnosis of thyroid storm per International Statistical Classification of Disease

SUBMITTER: Lee SY 

PROVIDER: S-EPMC10111182 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature