Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study.

ABSTRACT:

Objective

To estimate the effect of denosumab compared with oral bisphosphonates on reducing the risk of type 2 diabetes in adults with osteoporosis.

Design

Population based study involving emulation of a randomized target trial using electronic health records.

Setting

IQVIA Medical Research Data primary care database in the United Kingdom, 1995-2021.

Participants

Adults aged 45 years or older who used denosumab or an oral bisphosphonate for osteoporosis.

Main outcome measures

The primary outcome was incident type 2 diabetes, as defined by diagnostic codes. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence intervals, comparing denosumab with oral bisphosphonates using an as treated approach.

Results

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SUBMITTER: Lyu H 

PROVIDER: S-EPMC10111187 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature