Effect of histidine covalent modification on strigolactone receptor activation and selectivity.

ABSTRACT: The parasitic weed Striga has led to billions of dollars' worth of agricultural productivity loss worldwide. Striga detects host plants using compounds of the strigolactone class of phytohormones. Early steps in the strigolactone signaling pathway involve substrate binding and hydrolysis followed by a conformational change to an "active" or "closed" state, after which it associates with a MAX2-family downstream signaling partner. The structures of the inactive and active states of strigolactone receptors are known through X-ray crystallography, and the transition pathway from the inactive to active state in apo receptors has previously been characterized using molecular dynamics simulations. However, it also has been suggested that a covalent butenolide modification of the receptor on the

SUBMITTER: Chen J 

PROVIDER: S-EPMC10111262 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature