Dataset Information

The Association of Clustered Ventricular Arrhythmia and Cycle Length With Scar Burden in Cardiomyopathy.

ABSTRACT:

Background

Patients with ≥2 ventricular arrhythmia (VA) events within 3 months (clustered VA) have increased risk for mortality.

Objectives

The aim of this study was to examine the association of risk factors including scar characteristics on cardiovascular magnetic resonance imaging with clustered VA and VA cycle length in nonischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM).

Methods

Data from 329 primary prevention implantable cardioverter-defibrillator recipients (mean age 57 years, 26% women) were analyzed from the Left Ventricular Structural Predictors of Sudden Cardiac Death study.

Results

Twenty-one patients developed clustered VA (median time 2.7 years after implantable cardioverter-defibrillator placement). Men had the greatest risk for recurrent VA. Patients with NICM and scar had the highest incidence rate of clustered VA. In patients with NICM, each 1-g increase in core scar correlated with greater clustered VA risk (HR: 1.19; 95% CI: 1.07-1.32). Gray scar was similar among subgroups. Patients with NICM with clustered VA had the longest mean VA cycle length (297 ± 40 milliseconds). Higher core scar burden correlated with longer VA cycle length in patients with NICM (P = 0.002), and higher body mass index correlated with shorter VA cycle length in those with ICM (P = 0.02). Type of VA was similar between cardiomyopathy subgroups, and no scar pattern predominated.

Conclusions

Clustered VA was most common in patients with NICM and scar, with greatest risk among those with larger core scar. Core scar correlated with slower VA in patients with NICM, and higher body mass index correlated with faster VA in those with ICM. Type of VA was similar by cardiomyopathy etiology, and no dominant scar pattern was associated with clustered VA.

SUBMITTER: Vakil RM

PROVIDER: S-EPMC10111293 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

The Association of Clustered Ventricular Arrhythmia and Cycle Length With Scar Burden in Cardiomyopathy.

Vakil Rachit M RM Marine Joseph E JE Kolandaivelu Aravindan A Dickfeld Timm T Weiss Robert G RG Tomaselli Gordon F GF Chrispin Jonathan J Wu Katherine C KC

JACC. Clinical electrophysiology 20220727 8

<h4>Background</h4>Patients with ≥2 ventricular arrhythmia (VA) events within 3 months (clustered VA) have increased risk for mortality.<h4>Objectives</h4>The aim of this study was to examine the association of risk factors including scar characteristics on cardiovascular magnetic resonance imaging with clustered VA and VA cycle length in nonischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM).<h4>Methods</h4>Data from 329 primary prevention implantable cardioverter-defibrillator rec ...[more]

PMID: 35981800

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Dataset Information

The Association of Clustered Ventricular Arrhythmia and Cycle Length With Scar Burden in Cardiomyopathy.

Background

Objectives

Methods

Results

Conclusions

Publications

The Association of Clustered Ventricular Arrhythmia and Cycle Length With Scar Burden in Cardiomyopathy.

Similar Datasets

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