Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents.

ABSTRACT: Quaternary ammonium compounds (QACs) serve as a first line of defense against infectious pathogens. As resistance to QACs emerges in the environment, the development of next-generation disinfectants is of utmost priority for human health. Balancing antibacterial potency with environmental considerations is required to effectively counter the development of bacterial resistance. To address this challenge, a series of 14 novel biscationic quaternary phosphonium compounds (bisQPCs) have been prepared as amphiphilic disinfectants through straightforward, high-yielding alkylation reactions. These compounds feature decomposable or "soft" amide moieties in their side chains, anticipated to promote decomposition under environmental conditions. Strong bioactivity against a panel of seven bacterial

SUBMITTER: Brayton SR 

PROVIDER: S-EPMC10111419 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature