Mediation Effect of Obesity on the Association of Age at Menarche With Blood Pressure Among Women in Southwest China.

ABSTRACT: Background Previous studies have been inconsistent about the association between age at menarche and high blood pressure. Little is known about such association across a wide range of menarcheal ages in less developed ethnic minority regions in China. We aimed to explore the association between age at menarche and high blood pressure (BP; ≥140/90 mm Hg) and to examine the mediating effect of obesity and the moderating effect of menopausal status on this association. Methods and Results A total of 45 868 women from the baseline data of the CMEC (China Multi-Ethnic Cohort) were included in this study. Binary logistic regression was used to analyze the relationship between age at menarche and high BP, and the mediation model was used to evaluate the mediating effects of body mass index and wa

SUBMITTER: Chen J 

PROVIDER: S-EPMC10111443 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature