Impact of Concomitant Mitral Regurgitation on the Hemodynamic Indicators of Aortic Stenosis.

ABSTRACT: Background In patients with aortic stenosis (AS), the presence of mitral regurgitation (MR) can lead to underestimation of AS severity and worse clinical outcomes. The objective of this study was to characterize the magnitude of the effects of concomitant MR on hemodynamic indicators of AS severity using clinical data and a computational cardiovascular simulation. Methods and Results Echocardiographic data from 1427 patients with severe AS were used to inform a computational cardiovascular system model, and varying degrees of MR and AS were simulated. Hemodynamic data, including left ventricular and aortic pressure waveforms, were generated for all simulations. Simulated reduction in mean transaortic pressure gradient (MPG) associated with MR was then used to calculate the adjusted MPG in

SUBMITTER: Seman M 

PROVIDER: S-EPMC10111497 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature