Calcium Supplements and Risk of CVD: A Meta-Analysis of Randomized Trials.

ABSTRACT:

Background

Vitamin D supplements may only be beneficial for the prevention of osteoporotic fractures when administered with calcium and in individuals with low blood levels of 25(OH)D, but possible hazards of calcium supplements on CVD cannot be excluded.

Objectives

We conducted a meta-analysis of all placebo-controlled randomized trials assessing the effects of calcium supplements alone or with vitamin D on CHD, stroke, and all-cause mortality.

Methods

A meta-analysis of 11 trials included 7 comparisons of calcium alone compared with control (n = 8634) and 6 comparisons of calcium plus vitamin D compared with control (n = 46,804). Aggregated study-level data were obtained from individual trials and combined using a fixed-effects meta-analysis. The main

SUBMITTER: Huo X 

PROVIDER: S-EPMC10111600 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature