COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.

ABSTRACT:

Background

Despite overall improvement in breast cancer patient outcomes from earlier diagnosis and personalised treatment approaches, some patients continue to experience recurrence and incurable metastases. It is therefore imperative to understand the molecular changes that allow transition from a non-aggressive state to a more aggressive phenotype. This transition is governed by a number of factors.

Methods

As crosstalk with extracellular matrix (ECM) is critical for tumour cell growth and survival, we applied high throughput shRNA screening on a validated '3D on-top cellular assay' to identify novel growth suppressive mechanisms.

Results

A number of novel candidate genes were identified. We focused on COMMD3, a previously poorly characterised gene that suppressed

SUBMITTER: Hancock JL 

PROVIDER: S-EPMC10111822 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature