A novel potential inflammation-nutrition biomarker for predicting lymph node metastasis in clinically node-negative colon cancer.

ABSTRACT:

Background

The purpose of this study is to investigate the predictive significance of (platelet × albumin)/lymphocyte ratio (PALR) for lymph node metastasis (LNM) in patients with clinically node-negative colon cancer (cN0 CC).

Methods

Data from 800 patients with primary CC who underwent radical surgery between March 2016 and June 2021 were reviewed. The non-linear relationship between PALR and the risk of LNM was explored using a restricted cubic spline (RCS) function while a receiver operating characteristic (ROC) curve was developed to determine the predictive value of PALR. Patients were categorized into high- and low-PALR cohorts according to the optimum cut-off values derived from Youden's index. Univariate and multivariate logistic regression analyses were used to ide

SUBMITTER: Duan W 

PROVIDER: S-EPMC10111825 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature