Tracking the Emergence and Dissemination of a bla_NDM-23 Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae.

ABSTRACT: Since the discovery of bla_NDM-1, NDM β-lactamases have become one of the most widespread carbapenemases worldwide. To date, 43 different NDM variants have been reported but some, such as bla_NDM-23, have not been characterized in detail yet. Here, we describe the emergence of a novel bla_NDM-23 allele from a bla_NDM-1 ancestor and the multidrug resistance plasmid that has disseminated it through a Klebsiella pneumoniae ST437 clone in several Spanish hospitals. Between 2016 and 2019, 1,972 isolates were collected in an epidemiological survey for extended-spectrum-β-lactamase (ESBL)-producing Klebsiella pneumoniae in the Comunitat Valenciana (Spain). Three carbapenem-resistant strains failed to be detected by carbapenemase-

SUBMITTER: Garcia-Gonzalez N 

PROVIDER: S-EPMC10111884 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature