Valsartan, Losartan and Irbesartan use in the USA, UK, Canada and Denmark after the nitrosamine recalls: a descriptive cohort study.

ABSTRACT:

Objectives

To examine valsartan, losartan and irbesartan usage and switching patterns in the USA, UK, Canada and Denmark before and after July 2018, when the first Angiotensin-Receptor-Blocker (ARB) (valsartan) was recalled.

Design

Retrospective cohort study.

Setting

USA, Canadian administrative healthcare data, Danish National Prescription Registry and UK primary care electronic health records.

Participants

Patients aged 18 years and older between January 2014 and December 2020.

Intervention

Valsartan, losartan and irbesartan.

Main outcome

Monthly percentages of individual ARB episodes, new users and switches to another ARB, ACE inhibitors (ACEI) or calcium channel blockers containing products.

Results

We identified 10.8, 3.2, 1.8 and 1.2

SUBMITTER: Eworuke E 

PROVIDER: S-EPMC10111915 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature