Decreased breadth of the antibody response to the spike protein of SARS-CoV-2 after repeated vaccination.

ABSTRACT:

Introduction

The rapid development of vaccines to prevent COVID-19 has raised the need to compare the capacity of different vaccines in terms of developing a protective humoral response. Previous studies have shown inconsistent results in this area, highlighting the importance of further research to evaluate the efficacy of different vaccines.

Methods

This study utilized a highly sensitive and reliable flow cytometry method to measure the titers of IgG1 isotype antibodies in the blood of healthy volunteers after receiving one or two doses of various vaccines administered in Spain. The method was also used to simultaneously measure the reactivity of antibodies to the S protein of the original Wuhan strain and variants B.1.1.7 (Alpha), B.1.617.2 (Delta), and B.1.617.1 (Kappa).

SUBMITTER: Horndler L 

PROVIDER: S-EPMC10111966 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature