The role of early life adversity and inflammation in stress-induced change in reward and risk processes among adolescents.

ABSTRACT:

Background

Early life adversity (ELA) has long been associated with increased risk for stress-related psychopathology, particularly depression. The neuroimmune network hypothesis posits that ELA increases sensitivity to psychosocial stress, moderating the association between increases in peripheral markers of inflammation and decreases in reward outcomes linked to anhedonia and risk-taking behaviors. The present study examined this hypothesis in a sample of adolescents by using acute psychosocial stress to probe the role of inflammatory signaling in behavioral measures of reward and risk processing.

Method

80 adolescents [13.86 years (SD = 1.54); 45 % female], oversampled for ELA, underwent the Trier Social Stress Test for Children while providing blood samples immediately b

SUBMITTER: Kuhlman KR 

PROVIDER: S-EPMC10112053 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature