Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection.

ABSTRACT: The flavivirus life cycle is strictly dependent on cellular lipid metabolism. Polyphenols like gallic acid and its derivatives are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of lipid metabolism. The evaluation of our collection of polyphenols against West Nile virus (WNV), a representative medically relevant flavivirus, led to the identification of N,N'-(dodecane-1,12-diyl)bis(3,4,5-trihydroxybenzamide) and its 2,3,4-trihydroxybenzamide regioisomer as selective antivirals with low cytotoxicity and high antiviral activity (half-maximal effective concentrations [EC₅₀s] of 2.2 and 0.24 μM, respectively, in Vero cells; EC₅₀s of 2.2 and 1.9 μM, respectively, in SH-SY5Y ce

SUBMITTER: Jimenez de Oya N 

PROVIDER: S-EPMC10112131 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature