Poststress social isolation exerts anxiolytic effects by activating the ventral dentate gyrus.

ABSTRACT: After aversive stress, people either choose to return to their previously familiar social environment or tend to adopt temporary social withdrawal to buffer negative emotions. However, which behavior intervention is more appropriate and when remain elusive. Here, we unexpectedly found that stressed mice experiencing social isolation exhibited less anxiety than those experiencing social contact. Within the first 24 h after returning to their previous social environment, mice experienced acute restraint stress (ARS) displayed low social interest but simultaneously received excessive social disturbance from their cage mates, indicating a critical time window for social isolation to balance the conflict. To screen brain regions that were differentially activated between the poststress social i

SUBMITTER: Lei H 

PROVIDER: S-EPMC10112178 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature