SarS Is a Repressor of Staphylococcus aureus Bicomponent Pore-Forming Leukocidins.

ABSTRACT: Staphylococcus aureus is a successful pathogen that produces a wide range of virulence factors that it uses to subvert and suppress the immune system. These include the bicomponent pore-forming leukocidins. How the expression of these toxins is regulated is not completely understood. Here, we describe a screen to identify transcription factors involved in the regulation of leukocidins. The most prominent discovery from this screen is that SarS, a known transcription factor which had previously been described as a repressor of alpha-toxin expression, was found to be a potent repressor of leukocidins LukED and LukSF-PV. We found that inactivating sarS resulted in increased virulence both in an ex vivo model using primary human neutrophils and in an in vivo infection mode

SUBMITTER: Anderson EE 

PROVIDER: S-EPMC10112191 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature