In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.

ABSTRACT: Mycobacterium fortuitum represents one of the most clinically relevant rapid-growing mycobacterial species. Treatments are complex due to antibiotic resistance and to severe side effects of effective drugs, prolonged time of treatment, and co-infection with other pathogens. Herein, we explored the activity of NITD-916, a direct inhibitor of the enoyl-ACP reductase InhA of the type II fatty acid synthase in Mycobacterium tuberculosis. We found that this compound displayed very low MIC values against a panel of M. fortuitum clinical strains and exerted potent antimicrobial activity against M. fortuitum in macrophages. Remarkably, the compound was also highly efficacious in a zebrafish model of infection. Short duration treatments were sufficient to significantly protect the infected larvae f

SUBMITTER: Roquet-Baneres F 

PROVIDER: S-EPMC10112203 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature