Anticoagulation strategy and safety in critically ill COVID-19 patients: a French retrospective multicentre study.

ABSTRACT:

Background

Patients with critical illness due to COVID-19 exhibit increased coagulability associated with a high risk of venous thrombo-embolism (VTE). Data on prophylactic anticoagulation for these patients are limited and conflicting. The purpose of this study was to evaluate whether intermediate-dose prophylactic anticoagulation in patients with COVID-19 requiring ICU admission was associated with better outcomes compared to standard-dose prophylactic anticoagulation.

Methods

We retrospectively included adults admitted with severe COVID-19 to any of 15 ICUs, in 2020 or 2021. We compared the groups given intermediate-dose vs. standard-dose prophylactic anticoagulation. The primary outcome was all-cause day-90 mortality. Secondary outcomes were VTE (pulmonary embolism or de

SUBMITTER: Lamouche-Wilquin P 

PROVIDER: S-EPMC10112319 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature