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Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging.

ABSTRACT: SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via multimodal SWIR imaging.

SUBMITTER: East AK

PROVIDER: S-EPMC10112353 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging.

East Amanda K AK Lee Michael C MC Smaga Lukas P LP Jiang Chang C Mallojjala Sharath C SC Hirschi Jennifer S JS Chan Jefferson J

Organic letters 20221114 46

SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HDs)). In this study, we synthesized SWIR-HD, a modified HD featuring dimethylsilicon and benzo[cd]indolium groups that are designed to red-shift the absorbance and emission to 988 and 1126 nm, respectively. SWIR-HD was employed to visualize the liver and tumors via ...[more]

PMID: 36374323

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