Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort.

ABSTRACT:

Background

Large-scale Parkinson's disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European cohorts.

Methods

Using GWAS data from the largest study to date, we constructed a PD PRS for a Latino PD cohort (1497 subjects from LARGE-PD) and tested it for association with PD status and age at onset. We validated the PRS performance by testing it in an independent Latino cohort (448 subjects) and by repeating the analysis in LARGE-PD with the addition of 440 external Peruvian controls. We also tested SNCA haplotypes for association with PD risk in LARGE-PD and a European-ance

SUBMITTER: Loesch DP 

PROVIDER: S-EPMC10112543 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature