Seasonal variations in gut microbiota and disease course in patients with inflammatory bowel disease.

ABSTRACT:

Background and aim

Environmental factors are associated with onset and course of inflammatory bowel disease (IBD). Our previous study by about 1,100 IBD patients revealed half of the patients experienced seasonal exacerbation of disease. We investigated the seasonality of fecal microbiota composition of IBD patients.

Methods

Fecal samples were consecutively collected in each season from IBD outpatients and healthy controls between November 2015 and April 2019. Participants who were treated with full elemental diet or antibiotics within 6 months or had ostomates were excluded. Bacterial profiles were analyzed by 16S rRNA sequencing, and the changes between the diseases and seasons were compared.

Results

A total of 188 fecal samples were analyzed from 47 participants co

SUBMITTER: Tani M 

PROVIDER: S-EPMC10112787 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature