Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.

ABSTRACT: Commensal microbes in animals have a profound impact on tissue homeostasis, stress resistance, and ageing. We previously showed in Drosophila melanogaster that Acetobacter persici is a member of the gut microbiota that promotes ageing and shortens fly lifespan. However, the molecular mechanism by which this specific bacterial species changes lifespan and physiology remains unclear. The difficulty in studying longevity using gnotobiotic flies is the high risk of contamination during ageing. To overcome this technical challenge, we used a bacteria-conditioned diet enriched with bacterial products and cell wall components. Here, we demonstrate that an A. persici-conditioned diet shortens lifespan and increases intestinal stem cell (ISC) proliferation. Feeding adult flies a diet conditioned wi

SUBMITTER: Onuma T 

PROVIDER: S-EPMC10112789 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature