Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine.

ABSTRACT: Intestinal homeostasis depends on interactions between the intestinal epithelium, the immune system and the microbiota. Because of these complicated connections, there are many problems that need to be solved. Current research has indicated that genes targeted by Wnt signaling are responsible for controlling intestinal stem cell fate and for modulating intestinal homeostasis. Our data show that loss of frizzled 7 (Fzd7), an important element in Wnt signaling, interrupts the differentiation of mouse intestinal stem cells into absorptive progenitors instead of secretory progenitors (precursors of goblet and Paneth cells). The alteration in canonical Wnt and Notch signaling pathways interrupts epithelial homeostasis, resulting in a decrease in physical protection in the intestine. Several phe

SUBMITTER: Gu NX 

PROVIDER: S-EPMC10112897 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature