MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.

ABSTRACT: Hormone secretion from pancreatic islets is essential for glucose homeostasis, and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are crucial for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also in Neurog3+ endocrine progenitor cells, suggesting additional functions in cell differentiation and islet formation. Here, we report that MafB deficiency impairs β cell clustering and islet formation, but also coincides with loss of neurotransmitter and axon guidance receptor gene expression. Moreover, the observed loss of nicotinic receptor gene expression in human and mouse β cells implied that signaling through these recept

SUBMITTER: Bsharat S 

PROVIDER: S-EPMC10112931 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature