⁶⁸Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis.

ABSTRACT: Precise diagnosis of lymph node metastasis is important for therapeutic regimen planning, prognosis analysis and probably better outcomes for cancer patients. In this work, ⁶⁸Ga-labeled amphiphilic alternating copolymers nanoparticles with different rigid ligands were synthesized as positron emission tomography (PET) probes for lymph node metastasis imaging. The labeling efficiency and stability of nanoparticles was improved with increased rigidity of coordination unit. PU(⁶⁸Ga-L-MDI-PEG) nanoparticles (PU(⁶⁸Ga-L-MDI-PEG) NPs) with the strongest rigidity of coordination unit exhibited the lowest critical micelle concentration, the best ⁶⁸Ga labeling efficiency and stability. During in vivo lymph node metastasis imaging, PU(⁶⁸Ga-

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10112949 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature