Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression.

ABSTRACT:

Background and aims

Recent studies suggest that mitochondrial dysfunction promotes progression to NASH by aggravating the gut-liver status. However, the underlying mechanism remains unclear. Herein, we hypothesized that enhanced mitochondrial activity might reshape a specific microbiota signature that, when transferred to germ-free (GF) mice, could delay NASH progression.

Approach and results

Wild-type and methylation-controlled J protein knockout (MCJ-KO) mice were fed for 6 weeks with either control or a choline-deficient, L-amino acid-defined, high-fat diet (CDA-HFD). One mouse of each group acted as a donor of cecal microbiota to GF mice, who also underwent the CDA-HFD model for 3 weeks. Hepatic injury, intestinal barrier, gut microbiome, and the associated fecal metabol

SUBMITTER: Juarez-Fernandez M 

PROVIDER: S-EPMC10113004 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature