Research progress and clinical evaluation of histotripsy: a narrative review.

ABSTRACT:

Background and objective

As a soft-tissue noninvasive ablation technology, high-intensity focused ultrasound (HIFU) has been widely used to treat many clinical diseases. However, traditional HIFU, based on thermal effects, has a high local working temperature, which may cause thermal damage to surrounding tissues and reduce the therapeutic effect. Based on the cavitation effect of HIFU, histotripsy can mechanically destroy the cells in the target lesion. This paper aims to explain the mechanism of histotripsy, summarize the research progress of animal models for clinical evaluation and clinical application, and analyze the advantages and limitations of histotripsy.

Methods

Literature published from January 2006 to March 2022 was retrieved from the PubMed database. We reviewe

SUBMITTER: Li S 

PROVIDER: S-EPMC10113074 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature