Mitochondrial dynamics in neurological diseases: a narrative review.

ABSTRACT:

Background and objective

The mitochondrion is a crucial organelle for aerobic respiration and energy metabolism. It undergoes dynamic changes, including changes in its shape, function, and distribution through fission, fusion, and movement. Under normal conditions, mitochondrial dynamics are in homeostasis. However, once the balance is upset, the nervous system, which has high metabolic demands, will most likely be affected. Recent studies have shown that the imbalance of mitochondrial dynamics is involved in the occurrence and development of various neurological diseases. However, whether the regulation of mitochondrial dynamics can be used to treat neurological diseases is still unclear. We aimed to comprehensively analyze mitochondrial dynamics regulation and its potential role

SUBMITTER: Shen Y 

PROVIDER: S-EPMC10113088 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature