Diane-35 and metformin therapy in rats with endometrial lesions induced by dihydrotestosterone exposure.

ABSTRACT:

Background

Cotreatment with metformin and Diane-35 is conventionally used in the clinic to ameliorate ovulatory dysfunction and insulin resistance in women with polycystic ovary syndrome (PCOS). We previously showed that this combination treatment could reverse endometrial hyperplasia and endometrial cancer (EC) in patients with PCOS. Here, we aimed to investigate the influence of dihydrotestosterone (DHT) and this cotreatment on the endometrium, along with the related mechanisms.

Methods

We treated a DHT-exposed rat model with Diane-35 or metformin alone or their combination and investigated the 3-dimensional (3D) endometrial structure to determine the role of these treatments in reversing endometrial lesions and to clarify the underlying mechanisms. Uterine segments were m

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10113095 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature