Macrophage contribution to the survival of transferred expanded skin flap through angiogenesis.

ABSTRACT:

Background

Despite the application of tissue expansion in the reconstruction of significant tissue defects, complications with expanded random-pattern skin flaps remain a major challenge. Insufficient angiogenesis is one of the keys factors in flap ischemia and dysfunction. Macrophages play a key role in promoting tissue angiogenesis, but their effects on expanded flap angiogenesis and the survival of the transferred skin flap are still unknown.

Methods

A rat scalp expansion model was established to evaluate the dynamic changes of macrophages in expanded skin. Clodronate liposomes (Clo-lipo) were injected into the expanded scalps to deplete the macrophages, and the expanded scalp flaps with macrophage depletion were orthotopically transferred. The remaining expanded rat scal

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10113100 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature