Regulation of human trophoblast gene expression by endogenous retroviruses.

ABSTRACT: The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their capacity to quickly generate genetic variation and affect host gene regulation, may have helped to define species-specific trophoblast gene expression programs. Here we assess the contribution of transposable elements to human trophoblast gene expression as enhancers or promoters. Using epigenomic data from primary human trophoblast and trophoblast stem-cell lines, we identified multiple endogenous retrovirus families with regulatory potential that lie close to genes with preferential expression in trophoblast. These largely primate-specific elements are associa

SUBMITTER: Frost JM 

PROVIDER: S-EPMC10113160 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature