Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes.

ABSTRACT: Self-assembling peptides can be used for the regeneration of severely damaged skin. They can act as scaffolds for skin cells and as a reservoir of active compounds, to accelerate scarless wound healing. To overcome repeated administration of peptides which accelerate healing, we report development of three new peptide biomaterials based on the RADA16-I hydrogel functionalized with a sequence (AAPV) cleaved by human neutrophil elastase and short biologically active peptide motifs, namely GHK, KGHK and RDKVYR. The peptide hybrids were investigated for their structural aspects using circular dichroism, thioflavin T assay, transmission electron microscopy, and atomic force microscopy, as well as their rheological properties and stability in different fluids such as water or plasma, and their s

SUBMITTER: Dzierzynska M 

PROVIDER: S-EPMC10113214 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature