Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy.

ABSTRACT: Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has largely relied on a discrete parcellation of the striatum into distinct functional areas, but recent evidence suggests that the striatum comprises multiple overlapping and smoothly varying gradients (i.e., modes) of functional organization. Here, we investigated two of these functional connectivity modes, previously associated with variations in the topographic patterning of cortico-striatal connectivity (first-order gradient), and dopaminergic innervation of the striatum (second-order gradient), and assessed continuities in striatal function from subclinical to clinical domains. We applied connectopic mapping to resting-state fMRI data to obtain th

SUBMITTER: Oldehinkel M 

PROVIDER: S-EPMC10113219 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature