Population dynamics and drug resistance mutations in Plasmodium falciparum on the Bijagos Archipelago, Guinea-Bissau.

ABSTRACT: Following integrated malaria control interventions, malaria burden on the Bijagós Archipelago has significantly decreased. Understanding the genomic diversity of circulating Plasmodium falciparum malaria parasites can assist infection control, through identifying drug resistance mutations and characterising the complexity of population structure. This study presents the first whole genome sequence data for P. falciparum isolates from the Bijagós Archipelago. Amplified DNA from P. falciparum isolates sourced from dried blood spot samples of 15 asymptomatic malaria cases were sequenced. Using 1.3 million SNPs characterised across 795 African P. falciparum isolates, population structure analyses revealed that isolates from the archipelago cluster with samples from mainland West Africa and app

SUBMITTER: Moss S 

PROVIDER: S-EPMC10113324 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature