Resting-state functional connectivity disruption between the left and right pallidum as a biomarker for subthreshold depression.

ABSTRACT: Although the identification of late adolescents with subthreshold depression (StD) may provide a basis for developing effective interventions that could lead to a reduction in the prevalence of StD and prevent the development of major depressive disorder, knowledge about the neural basis of StD remains limited. The purpose of this study was to develop a generalizable classifier for StD and to shed light on the underlying neural mechanisms of StD in late adolescents. Resting-state functional magnetic resonance imaging data of 91 individuals (30 StD subjects, 61 healthy controls) were included to build an StD classifier, and eight functional connections were selected by using the combination of two machine learning algorithms. We applied this biomarker to an independent cohort (n = 43) and c

SUBMITTER: Sato Y 

PROVIDER: S-EPMC10113366 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature