Statistical control of structural networks with limited interventions to minimize cellular phenotypic diversity represented by point attractors.

ABSTRACT: The underlying genetic networks of cells give rise to diverse behaviors known as phenotypes. Control of this cellular phenotypic diversity (CPD) may reveal key targets that govern differentiation during development or drug resistance in cancer. This work establishes an approach to control CPD that encompasses practical constraints, including model limitations, the number of simultaneous control targets, which targets are viable for control, and the granularity of control. Cellular networks are often limited to the structure of interactions, due to the practical difficulty of modeling interaction dynamics. However, these dynamics are essential to CPD. In response, our statistical control approach infers the CPD directly from the structure of a network, by considering an ensemble average fun

SUBMITTER: Kim J 

PROVIDER: S-EPMC10113376 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature