Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population.

ABSTRACT:

Aims

Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are different. Therefore, we explored HbA1c- and blood glucose-associated loci in a non-diabetic Japanese population.

Methods

We conducted a two-stage genome-wide association study (GWAS) on variants associated with HbA1c and blood glucose levels in a Japanese population. In the initial stage, data of 4911 participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) were subjected to discovery analysis. In the second stage, two datasets from the Tohoku Medical Megabank project, with 8175 and 40,519 participants, were used for the replication study. Association of the imputed variants with HbA1c and blood glucose levels

SUBMITTER: Sakashita T 

PROVIDER: S-EPMC10113415 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature