L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults.

ABSTRACT:

Introduction

Millions of people worldwide take medications such as L-DOPA that increase dopamine to treat Parkinson's disease. Yet, we do not fully understand how L-DOPA affects sleep and memory. Our earlier research in Parkinson's disease revealed that the timing of L-DOPA relative to sleep affects dopamine's impact on long-term memory. Dopamine projections between the midbrain and hippocampus potentially support memory processes during slow wave sleep. In this study, we aimed to test the hypothesis that L-DOPA enhances memory consolidation by modulating NREM sleep.

Methods

We conducted a double-blind, randomised, placebo-controlled crossover trial with healthy older adults (65-79 years, n = 35). Participants first learned a word list and were then administered long-

SUBMITTER: Isotalus HK 

PROVIDER: S-EPMC10113484 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature